FLOXM-DT Tablet

INDICATIONS:

FLOXIM is indicated in the treatment of the following infections caused by susceptible organisms

1. Urinary tract infections

2. Upper and lower respiratory tract infections

3. Acute otitis media.

4. Gonococcal urethritis

5. Typhoid.

DOSAGE AND DIRECTION FOR USE:

FLOXIM by oral administration

The usual adult of Cefixime (anhydrous) is 200-400mg per day administered orally, either as a single dose or in two divided doses, although lower doses may prove sufficient to treat uncomplicated urinary tract infections.

For children: 8mg/kg daily, as either a single dose or in two divided doses, is recommended. In uncomplicated gonococcal urethritis, a single oral dose of 400mg has been found to be effective. Or as directed by the physician.

Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As cefixime is third generation cephalosporin, it is not contraindicated for patients with a true penicillin allergy.

Cefixime is generally well tolerated. Majority of adverse reactions in clinical trials were mild and self-limiting in nature.

The most frequent side effects seen with cefixime are diarrhoea and stool changes, diarrhoea has been more commonly associated with higher doses. Some cases of moderate to severe diarrhoea have been reported, this has occasionally warranted cessation of therapy. Other side effects include headache and dizziness. Mild transient changes in liver and renal function test have been observed. Allergies in the form of rash pruritus, urticaria, drug fever and arthralgia have been observed.

In common with other cephalosporins, increase in prothrombin times has been noted in a few patients. Care should therefore be taken in patients receiving anticoagulation therapy.

FLOXIM should not be used in pregnancy or in nursing mothers unless considered essential by the physician.

The possibility of the emergence of resistant organism which might result in overgrowth should be kept in mind, particularly during prolonged treatment.

FLOXIM should be used with caution in patients with marked renal impairment.