TAXIM-O Tablet

គុណភាពព្យាបាល៖

ឱសថនេះជាថ្នាំផ្សះអង់ទីប៊ីយ៉ូទិកស្ថិតក្នុងក្រុម Cephalosporin ជំនាន់ទី៣ ប្រើក្នុងការព្យាបាល៖

- ជំងឺផ្លូវទឹកមូត្រ មិនស្មុគស្មាញ បង្កដោយមេរោគ Escherichis Coli, Proteus mirabills

- ជំងឺរលាកបំពង់ក រលាកអាមីដាល បង្កដោយមេរោគ S.pyogenes

- រលាកត្រចៀក បំពង់សំឡេង បង្កឡើងដោយមេរោគ H.influenza

- ជំងឺប្រមះមិនស្មុគស្មាញ រលាកស្បូន រលាកបង្ហួរនោម បង្កដោយមេរោគ N.gonorrhoeae

កំណត់សម្គាល់៖ ជំងឺខាងលើអាចព្យាបាលដំបូងដោយឱសថ Penicilline បាន រីឯ Taxim-O វិញគួរប្រើក្នុងករណីសម្លាប់មេរោគផ្តាច់ពូជ។

កម្រិត និងរបៀបប្រើ៖

- ចំពោះមនុស្សពេញវ័យ៖ កម្រិតប្រើគឺ 400ម.ក្រ ក្នុង១ថ្ងៃ (២គ្រាប់)។ លេបម្តង ១គ្រាប់ (២០០ម.ក្រ) ១ថ្ងៃ ២ដង (ចន្លោះ១២ម៉ោងម្តង)។

 +ព្យាបាលជំងឺប្រមេះ ធ្លាក់ស រលាកស្បូន រលាកផ្លូវបង្ហួរនោម៖ លេបម្តង ២គ្រាប់ (៤០០ម.ក្រ) ១ថ្ងៃ ១ដង។

- ចំពោះកុមារ៖ គួរប្រើថ្នាំទឹកស៊ឺរ៉ូមខាប់។ កម្រិតប្រើគឺ ៨ម.ក្រ/គ.ក្រ/ថ្ងៃ ដោយចែកផឹកជា ២ដងក្នុង១ថ្ងៃ (ព្រឹកម្តង ល្ងាចម្តង)។

 +កុមារអាយុលើសពី ១២ឆ្នាំ (ទម្ងន់លើសពី ៥០គ.ក្រ) អាចប្រើកម្រិតមនុស្សពេញវ័យបាន។

Microbiology: As with other cephalosporins, bactericidal action of cefixime results from inhabitation of cell-wall synthesis, Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamase, may be susceptible to cefixime. Cefixime has been shown to be active against most strain of both in vitro and in clinical infections.

Indications and Usage:

In the treatment of the following infections when caused by susceptible strains of the designated microorganisms: Uncomplicated Urinary Tract Infections, caused by Escherichia coli and Proteus mirabillis.

Otitis Media caused by Haemophilus influenzae (beta-lactamase positive and negative strain), Moraxella (Branhamella) catarrhalis (most of which are beta-lactamase positive) and S.pyogenes.

Pharyngitis and Tonsillitis caused by S.pyogenes.

Note: Penicillin is the usual drug of choice in the treatment of S.pyogenes infections, including the prophylaxis of rheumatic fever. Cefixime is generally effective in the eradication of Streptococcus pyogenes from the nasopharynx; however, data establishing the efficacy of cefixime in the subsequent prevention of rheumatic fever are not available.

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis, caused by Streptococcus pneumoniae and Haemophillus influenzae (beta lactamase positive and negative strains).

Uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).

Dosage and administration

Take with food or milk to avoid stomach upset.

Adults: 400mg daily. (400mg once daily or 200mg every 12 hours)

For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400mg is recommended.

Children: 8mg/kg/day (as a single daily dose or in two divided doses, as 4mg/kg/every 12 hours).

Children weighing more than 50kg or older than 12 years should be treated with the recommended adult dose.

ចំពោះអ្នកធ្លាប់មានប្រតិកម្មជាមួយឱសថក្រុម Cephalosporin។

In contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

ភាគច្រើនមានលក្ខណៈស្រាល និងអន្តរកាលដូចជា៖ រាក លាមករាវ ឈឺពោះ ពិបាករំលាយអាហារ ចង្អោរក្អួត។ ក្នុងករណីកម្រ៖ រលាកពោះវៀនធំ ស្បែកឡើងកន្ទួលរមាស់ក្រហម ក្តៅខ្លួន ប៉ះពាល់ដល់គ្រាប់ឈាម និងលទ្ធផលមន្ទីរពិសោធន៍

Most of adverse reactions observed in clinical trials were of a mild and transient nature.

Gastrointestinal: Diarrhoea, loose stools, abdominal pain, dyspepsia, nausea, and vomiting.

Several cases of documented pseudomembranous colitis were identified during the studies.

Hypersensitivity Reaction: Skin rashes, urticaria, drug fever, and pruritus. Erythema multiforme, Stevens-Johnson syndrome, and serum sickness-like reactions have been reported.

Abnormal Laboratory Tests: Positive direct Coombs test, elevated bilirubin, elevated LDH, neutropenia, arganulocy tosis.

អន្តរកម្មឱសថ៖ ពុំមានអន្តរកម្មឱសថ គួរឱ្យកត់សម្គាល់ទេ។

No significant drug interactions have been reported to date.

This antibiotic may decrease the effectiveness of birth controls pills; use another form of birth control while taking this medication.

Cefixime may cause a false-positive reaction for nonspecific urine glucose tests in patients with diabetes.

This medication dose not interfere with enzyme-base urine glucose tests.

គួរជៀសវាងប្រើចំពោះស្រី្តមានផ្ទៃពោះ និងស្ត្រីទើបសម្រាលកូន លើកលែងមានការចាំបាច់ខ្លាំង។

Pregnancy: Category B

Reproduction studies have been performed in mice and rats at dose up to 400 times the human dose and have revealed no evidence of harm to the fetus due to cefixime.

There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Labour and Delivery: Cefixime has not been studied for use during labour and delivery. Treatment should only be given if clearly needed.

Nursing Mothers: It is not known whether cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with this drug.

Pediatric Use: See the package insert about the details.

- មុនប្រើឱសថនេះត្រូវធ្វើតេស្តត្រួតពិនិត្យ Sensibility ដើម្បីធានាថា អ្នកជំងឺពុំំមានប្រតិកម្មអាល្លែកហ្ស៊ី ជាមួយឱសថក្រុម Cephalosporin, Penicillin, និងឱសថផ្សេងៗទេ។ អ្នកជំងឺ ១០% ដែលប្រតិកម្មជាមួយ Penicillin អាចមានប្រតិកម្មជាមួយ (តាក់ស៊ីម-អូ) ដែលទាមទារការព្យាបាលបន្ទាន់។
- ការប្រើឱសថនេះរយៈពេលយូរ អាចបង្កើតនូវមេរោគថ្មីដែលស៊ាំនឹងឱសថនេះ (ជំងឺថ្មី) ដែលទាមទារការព្យាបាលបន្ទាន់។
- ត្រូប្រើឱសថនេះដោយប្រុងប្រយ័ត្នចំពោះអ្នកធ្លាប់មានប្រវត្តិជំងឺក្រពះ-ពោះវៀន ពិសេសជំងឺរលាកពោះវៀនធំ។

Before therapy with cefixime is instituted, careful inquiry should be made to determine whether the patient has had previous hypersensitivity reactions to cephalosporins, penicillin, or other drugs, if this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibiotics has been clearly documented and may occurs up to 10% of patients with a history of penicillin allergy. If an allergic reaction of cefixime occurs, discontinue the drug, serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, presoor amines and airway management, as clinically indicated.

Antibiotics including cefixime, should be administered cautiously to any patient who has demonstrated some form of allergy, particularly to drugs.

General: The possibly of the emergence of resistant organisms which might result in overgrowth should be kept in mind, particularly during prolonged treatment. In use, careful observation of the patient in essential. If superinfection occurs during therapy, appropriate measures should be taken.

Cefixime should be prescribed with caution in individual with a history of gastrointestinal disease, particularly colitis.

Drug/Laboratory Test Interactions: A false-positive reaction for ketones in the urine may occur with tests using nitroprusside but not with those using nitroferricyanide.

Carcinogenesis, Mutagenesis, and Impairment of Fertility: See the package insert about the details.